Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Genomics - from Neanderthals to high-throughput sequencing. | Meeting report Genomics - from Neanderthals to high-throughput sequencing Matthew John Wakefield Address ARC Centre for Kangaroo Genomics Bioinformatics Division The Walter and Eliza Hall Institute 1G Royal Parade Parkville 3050 Australia. Email wakefield@ Published 24 August 2006 Genome Biology 2006 7 326 doi gb-2006-7-8-326 The electronic version of this article is the complete one and can be found online at http 2006 7 8 326 2006 BioMed Central Ltd A report on The Biology of Genomes meeting Cold Spring Harbor USA 10-14 May 2006. This year the emphasis of The Biology of Genomes meeting held in May at the Cold Spring Harbor Laboratory was on the plural with population genomics and comparative genomics taking center stage. The initial challenge of genomics was to efficiently generate the vast amount of data required to assemble genome sequences and to apply our knowledge to sensible annotation of this deluge of data. Although these tasks are continuing the new challenges are not only to scale up traditional experiments to previously unimagined levels but to leverage our knowledge to forge truly new discoveries. Next-generation DNA sequencing Genomics is still driven and directed by advancements and limitations of sequencing technology. After a long incubation the first effects of the next-generation sequencing platforms are now being felt. Two new high-throughput platforms for ultrarapid DNA sequencing were in evidence. The GenomeSequencer 20 GS20 platform has been developed by 454 Life Sciences Branford USA and uses bead-attached DNA fragments as templates and pyrosequencing a sequencing-by-synthesis technique in which the number of incorporations of a given base is detected by the intensity of a light signal. The Clonal Single Molecule Array platform from Solexa based in Little Chesterford UK uses amplification of clusters of DNA fragments on glass slides and sequencing-by-synthesis adding one base at a time using reversible .
