Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Functional genomics of the yeast DNA-damage response. | Minireview Functional genomics of the yeast DNA-damage response Gerard Cagney David Alvaro Robert JD Reid Peter H Thorpe Rodney Rothstein and Nevan J Krogan Addresses Conway Institute University College Dublin Belfield Dublin 4 Ireland. Department of Genetics and Development Columbia University Medical Center New York NY 10032 USA. Department of Cellular and Molecular Pharmacology and California Institute for Quantitative Biomedical Research University of California-San Francisco 1700 4th Street San Francisco CA 94143 USA. Correspondence Nevan J Krogan. Email krogan@ Published 7 September 2006 Genome Biology 2006 7 233 doi gb-2006-7-9-233 The electronic version of this article is the complete one and can be found online at http 2006 7 9 233 2006 BioMed Central Ltd Abstract High-throughput approaches are beginning to have an impact on many areas of yeast biology. Two recent studies using different experimental platforms provide insight into new pathways involved in the response of yeast to DNA damage. Large-scale sequencing projects in the 1990s ushered in a series of genome-wide studies aimed at addressing gene function. Termed functional genomics or in some contexts systems biology 1 a decade of work on the budding yeast Saccharomyces cerevisiae has resulted in a body of knowledge describing gene-expression patterns gene-disruption phenotypes and protein-protein and protein-DNA interactions. While certain levels of experimental error are associated with these data analyses have shown that combinations of the individual datasets result in gene function predictors of considerable power 2 . Two recent studies 3 4 have taken these observations into account and describe work aimed at further characterizing the yeast response to DNA damage by using different and complementary experimental platforms. The DNA-damage response has been a target of high-throughput studies because of its complexity as well as its relevance to human .
