Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Multiple effects govern endogenous retrovirus survival patterns in human gene introns. | Research Open Access Multiple effects govern endogenous retrovirus survival patterns in human gene introns Louie N van de Lagemaat Patrik Medstrand and Dixie L Mager Addresses Terry Fox Laboratory BC Cancer Research Centre 675 W 10th Avenue Vancouver BC V5Z 1L3 Canada. Department of Medical Genetics University of British Columbia BC V6T 1Z3 Canada. Department of Experimental Medical Sciences Lund University BMC B13 221 84 Lund Sweden. Correspondence Dixie L Mager. Email dmager@ Published 27 September 2006 Genome Biology 2006 7 R86 doi 186 gb-2006-7-9-r86 The electronic version of this article is the complete one and can be found online at http 2006 7 9 R86 Received 6 July 2006 Revised 25 August 2006 Accepted 27 September 2006 2006 van de Lagemaat et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Endogenous retroviruses ERVs and solitary long terminal repeats LTRs have a significant antisense bias when located in gene introns suggesting strong negative selective pressure on such elements oriented in the same transcriptional direction as the enclosing gene. It has been assumed that this bias reflects the presence of strong transcriptional regulatory signals within LTRs but little work has been done to investigate this phenomenon further. Results In the analysis reported here we found significant differences between individual human ERV families in their prevalence within genes and degree of antisense bias and show that regardless of orientation ERVs of most families are less likely to be found in introns than in intergenic regions. Examination of density profiles of ERVs across transcriptional units and the transcription signals present in the consensus ERVs suggests the
