Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Mining the Arabidopsis thaliana genome for highly-divergent seven transmembrane receptors. | Open Access Method Mining the Arabidopsis thaliana genome for highly-divergent seven transmembrane receptors Etsuko N Moriyama Pooja K Strope Stephen O Opiyo Zhongying Chen and Alan M Jones Addresses School of Biological Sciences and Plant Science Initiative University of Nebraska-Lincoln Lincoln NE 68588-0660 USA. Department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE 68583-0915 USA. Departments of Biology and Pharmacology University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA. Correspondence Etsuko N Moriyama. Email emoriyama2@ Published 25 October 2006 Genome Biology 2006 7 R96 doi gb-2006-7-l 0-r96 The electronic version of this article is the complete one and can be found online at http 2006 7 l0 R96 Received 28 June 2006 Revised 24 August 2006 Accepted 25 October 2006 2006 Moriyama et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract To identify divergent seven-transmembrane receptor 7TMR candidates from the Arabidopsis thaliana genome multiple protein classification methods were combined including both alignmentbased and alignment-free classifiers. This resolved problems in optimally training individual classifiers using limited and divergent samples and increased stringency for candidate proteins. We identified 394 proteins as 7TMR candidates and highlighted 54 with corresponding expression patterns for further investigation. Background Seven-transmembrane 7TM -region containing proteins constitute the largest receptor superfamily in vertebrates and other metazoans. These cell-surface receptors are activated by a diverse array of ligands and are involved in various signaling processes such as cell proliferation neurotransmission .
