Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of novel regulatory modules in dicotyledonous plants using expression data and comparative genomics. | Open Access Research Identification of novel regulatory modules in dicotyledonous plants using expression data and comparative genomics Klaas Vandepoele Tineke Casneuf and Yves Van de Peer Address Department of Plant Systems Biology Flanders Interuniversity Institute for Biotechnology VIB Ghent University Technologiepark B-9052 Ghent Belgium. Correspondence Yves Van de Peer. Email Published 7 November 2006 Genome Biology 2006 7 RI03 doi gb-2006-7- 11-r103 The electronic version of this article is the complete one and can be found online at http 2006 7 II RI03 Received 14 June 2006 Revised 15 September 2006 Accepted 7 November 2006 2006 Vandepoele et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Transcriptional regulation plays an important role in the control of many biological processes. Transcription factor binding sites TFBSs are the functional elements that determine transcriptional activity and are organized into separable c s-regulatory modules each defining the cooperation of several transcription factors required for a specific spatio-temporal expression pattern. Consequently the discovery of novel TFBSs in promoter sequences is an important step to improve our understanding of gene regulation. Results Here we applied a detection strategy that combines features of classic motif overrepresentation approaches in co-regulated genes with general comparative footprinting principles for the identification of biologically relevant regulatory elements and modules in Arab dops s thal ana a model system for plant biology. In total we identified 80 TFBSs and I39 regulatory modules most of which are novel and primarily consist of two or three .
