Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors. | Open Access Research Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors Margarida Gama-Carvalho Nuno L Barbosa-Morais Alexander S Brodsky Pamela A Silver and Maria Carmo-Fonseca Addresses Instituto de Medicina Molecular Faculdade de Medicina Universidade de Lisboa Av. Prof. Egas Moniz 1649-028 Lisboa Portugal. tHutchison MRC Research Centre Department of Oncology University of Cambridge Hills Road Cambridge CB2 0XZ UK. Department of Systems Biology Harvard Medical School 200 Longwood Ave Alpert 536 Boston MA 02115 USA. Department of Molecular Biology Cell Biology and Biochemistry and Center for Genomics Proteomics Brown University 69 Brown Street Providence Rhode Island 02912 USA. Correspondence Margarida Gama-Carvalho. Email Published 30 November 2006 Received 31 July 2006 Genome Biology 2006 7 R113 doi gb-2006-7- 11-r113 The electronic version of this article is the complete one and can be found online at http 2006 7 11 R1 13 Revised 18 October 2006 Accepted 30 November 2006 2006 Gama-Carvalho et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Pre-mRNA splicing is an essential step in gene expression that occurs co-transcriptionally in the cell nucleus involving a large number of RNA binding protein splicing factors in addition to core spliceosome components. Several of these proteins are required for the recognition of intronic sequence elements transiently associating with the primary transcript during splicing. Some protein splicing factors such as the U2 small nuclear RNP auxiliary factor U2AF are known to be exported to the cytoplasm despite .
