Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Genome Science Laboratory, Discovery Research Institute, RIKEN Wako Institute,. | Research Open Access Dynamic usage of transcription start sites within core promoters Hideya Kawaji Martin C Frith Shintaro Katayama Albin Sandelin Chikatoshi Kai Jun Kawai Piero Carninci and Yoshihide HayashizakH Addresses NTT Software Corporation 209 Yamashita-cho Nakak-ku Yokohama Kanagawa 231-8551 Japan. Genome Exploration Research Group Genome Network Project Core Group RIKEN Genomic Sciences Center GSC RIKEN Yokohama Institute 1-7-22 Suehiro-cho Tsurumi-ku Yokohama Kanagawa 230-0045 Japan. Institute for Molecular Bioscience University of Queensland 306 Carmody Road Brisbane Queensland 4072 Australia. The Bioinformatics Centre University of Copenhagen Universitetsparken 15 DK-2100 Kobenhavn 0 Denmark. Genome Science Laboratory Discovery Research Institute RIKEN Wako Institute 2-1 Hirosawa Wako Saitama 351-0198 Japan. Correspondence Hideya Kawaji. Email kawaji@. Shintaro Katayama. Email rgscerg@ Published 12 December 2006 Genome Biology 2006 7 R118 doi gb-2006-7- 12-r118 The electronic version of this article is the complete one and can be found online at http 2006 7 12 R1 18 Received 31 July 2006 Revised 26 October 2006 Accepted 12 December 2006 2006 Kawaji et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Mammalian promoters do not initiate transcription at single well defined base pairs but rather at multiple alternative start sites spread across a region. We previously characterized the static structures of transcription start site usage within promoters at the base pair level based on large-scale sequencing of transcript 5 ends. Results In the present study we begin to explore the internal dynamics of mammalian promoters and demonstrate .
