Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Multiple independent evolutionary solutions to core histone gene regulation. | Open Access Research Multiple independent evolutionary solutions to core histone gene regulation Leonardo Marino-Ramirez I King Jordan and David Landsman Addresses Computational Biology Branch National Center for Biotechnology Information National Institutes of Health 8600 Rockville Pike Bethesda Maryland 20894-6075 USA. School of Biology Georgia Institute of Technology 310 Ferst Drive Atlanta Georgia 30332-0230 USA. Correspondence David Landsman. Email landsman@ Published 21 December 2006 Genome Biology 2006 7 RI22 doi gb-2006-7- 12-r 122 The electronic version of this article is the complete one and can be found online at http 2006 7 I2 RI22 Received 8 August 2006 Revised 20 October 2006 Accepted 21 December 2006 2006 Marino-Ramirez et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Core histone genes are periodically expressed along the cell cycle and peak during S phase. Core histone gene expression is deeply evolutionarily conserved from the yeast Saccharomyces cerevisiae to human. Results We evaluated the evolutionary dynamics of the specific regulatory mechanisms that give rise to the conserved histone regulatory phenotype. In contrast to the conservation of core histone gene expression patterns the core histone regulatory machinery is highly divergent between species. There has been substantial evolutionary turnover of cis-regulatory sequence motifs along with the transcription factors that bind them. The regulatory mechanisms employed by members of the four core histone families are more similar within species than within gene families. The presence of species-specific histone regulatory mechanisms is opposite to what is seen at the protein sequence
