Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling. | Open Access Research Impairment of organ-specific T cell negative selection by diabetes susceptibility genes genomic analysis by mRNA profiling Adrian Liston Kristine Hardy Yvonne Pittelkow Susan R Wilson Lydia E Makaroff Aude M Fahrer and Christopher C Goodnow Addresses John Curtin School of Medical Research The Australian National University Canberra ACT 2601 Australia. Mathematical Sciences Institute The Australian National University Canberra ACT 2601 Australia. Biochemistry and Molecular Biology The Australian National University Canberra ACT 2601 Australia. The Australian Phenomics Facility The Australian National University Canberra ACT 2601 Australia. Department of Immunology University of Washington Seattle WA 98195 USA. Correspondence Christopher C Goodnow. Email Published 21 January 2007 Genome Biology 2007 8 R12 doi gb-2007-8-1-r12 The electronic version of this article is the complete one and can be found online at http 2007 8 1 R12 Received 29 August 2006 Revised 23 October 2006 Accepted 21 January 2007 2007 Liston et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background T cells in the thymus undergo opposing positive and negative selection processes so that the only T cells entering circulation are those bearing a T cell receptor TCR with a low affinity for self. The mechanism differentiating negative from positive selection is poorly understood despite the fact that inherited defects in negative selection underlie organ-specific autoimmune disease in A RE-deficient people and the non-obese diabetic NOD mouse strain Results Here we use homogeneous populations of T cells undergoing either positive or negative selection in vivo together with .
