Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Expanding the mitochondrial interactome. | Minireview Expanding the mitochondrial interactome Timothy E Shutt and Gerald S Shadel Address Department of Pathology Yale University School of Medicine Cedar Street New Haven CT 06520-8023 USA. Correspondence Gerald S Shadel. Email Published 23 February 2007 Genome Biology 2007 8 203 doi gb-2007-8-2-203 The electronic version of this article is the complete one and can be found online at http 2007 8 2 203 2007 BioMed Central Ltd Abstract The integration of information on different aspects of the composition and function of mitochondria is defining a more comprehensive mitochondrial interactome and elucidating its role in a multitude of cellular processes and human disease. Mitochondria are complex dynamic and essential organelles in eukaryotic cells. They are remarkable structures with well-known functions such as the production of ATP via oxidative phosphorylation and a role in apoptosis. In addition they are now being implicated in novel cellular functions for example oxygen sensing signal transduction and anti-viral mechanisms . Mitochondrial dysfunction is also increasingly being shown to be relevant in disease age-related and environmentally induced pathology and the aging process itself 1 . Mitochondria contain a DNA genome mtDNA clear evidence of their past as a free-living bacterium related to the present-day a-proteobacteria that became engulfed in an ancestral eukaryotic cell billion years ago 2 . In most eukaryotes mtDNA now primarily encodes a small but essential subset of genes required for oxidative phosphorylation for example the human mtDNA molecule harbors 37 genes 13 mRNAs specifying oxidative phosphorlaytion subunits 22 tRNAs and 2 rRNAs 3 . The proteins encoded in mtDNA are expressed in the mitochondrion but the complete mitochondrial proteome is the product of two genomes as most mitochondrial proteins are transcribed from genes in the nucleus translated by cytoplasmic ribosomes and .
