Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: DarkHorse: a method for genome-wide prediction of horizontal gene transfer. | Open Access Metlfccl DarkHorse a method for genome-wide prediction of horizontal gene transfer Sheila Podell and Terry Gaasterland Address Scripps Genome Center Scripps Institution of Oceanography University of California at San Diego Gilman Drive La Jolla CA 920930202 USA. Correspondence Sheila Podell. Email spodell@ Published 2 February 2007 Genome Biology 2007 8 R16 doi gb-2007-8-2-r16 The electronic version of this article is the complete one and can be found online at http 2007 8 2 R16 Received 4 August 2006 Revised 9 November 2006 Accepted 2 February 2007 2007 Podell et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract A new approach to rapid genome-wide identification and ranking of horizontal transfer candidate proteins is presented. The method is quantitative reproducible and computationally undemanding. It can be combined with genomic signature and or phylogenetic tree-building procedures to improve accuracy and efficiency. The method is also useful for retrospective assessments of horizontal transfer prediction reliability recognizing orthologous sequences that may have been previously overlooked or unavailable. These features are demonstrated in bacterial archaeal and eukaryotic examples. Background Horizontal gene transfer can be defined as the movement of genetic material between phylogenetically unrelated organisms by mechanisms other than parent to progeny inheritance. Any biological advantage provided to the recipient organism by the transferred DNA creates selective pressure for its retention in the host genome. A number of recent reviews describe several well-established pathways of horizontal transfer 1-4 . Evidence for the unexpectedly high frequency of .
