Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The ring between ring fingers (RBR) protein family. | Protein family review The ring between ring fingers RBR protein family Birgit Eisenhaber Nina Chumak Frank Eisenhaber and Marie-Theres Hauser Addresses Research Institute of Molecular Pathology IMP Dr Bohr-Gasse A-1030 Vienna Austria. Institute of Applied Genetics and Cell Biology Department of Plant Science and Plant Biotechnology University of Natural Resources and Applied Life Sciences Muthgasse A-1190 Vienna Austria. Correspondence Birgit Eisenhaber. Email . Marie-Theres Hauser. Email Published 15 March 2007 Genome Biology 2007 8 209 doi gb-2007-8-3-209 The electronic version of this article is the complete one and can be found online at http 2007 8 3 209 2007 BioMed Central Ltd Summary Proteins of the ring between ring fingers RBR -domain family are characterized by three groups of specifically clustered typically eight cysteine and histidine residues. Whereas the aminoterminal ring domain N-RING binds two zinc ions and folds into a classical cross-brace ring finger the carboxy-terminal ring domain C-RING involves only one zinc ion. The threedimensional structure of the central ring domain the IBR domain is still unsolved. About 400 genes coding for RBR proteins have been identified in the genomes of uni- and multicellular eukaryotes and some of their viruses but the family has not been found in archaea or bacteria. The RBR proteins are classified into l5 major subfamilies besides some orphan cases by the phylogenetic relationships of the RBR segments and the conservation of their sequence architecture. The RBR domain mediates protein-protein interactions and a subset of RBR proteins has been shown to function as E3 ubiquitin ligases. RBR proteins have attracted interest because of their involvement in diseases such as parkinsonism dementia with Lewy bodies and Alzheimer s disease and in susceptibility to some intracellular bacterial pathogens. Here we present an .
