Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The power of two experimental designs for detecting linkage between a marker locus and a locus affecting a quantitative character in a segregating population | Genet Sei Evol 1993 25 249-261 Elsevier INRA 249 Original article The power of two experimental designs for detecting linkage between a marker locus and a locus affecting a quantitative character in a segregating population zw Luo University of Edinburgh Institute of Cell Animal and Population Biology King s Buildings Edinburgh EH 9 3JT UK Received 14 November 1991 accepted 9 February 1993 Summary - The statistical power of 2 experimental designs backcrossing and intercrossing for detecting linkage between a marker gene and a quantitative trait locus QTL in families derived from a segregating population is investigated. Formulae which relate power to the recombination frequency r between the genes the genetical properties of the quantitative trait controlled by the QTL and the design parameters are developed. The reliability of some simplifying assumptions was confirmed by computer simulations. Application of these formulae has shown that the power of the 2 designs with population size of 1 000 was 20 when r was for all heritabilities of single gene considered few large families are better than many small families and backcrossing is generally more efficient than intercrossing. The allele frequencies and dominance properties of the QTLs have important interactions in their effects on power. statistical power marker QTL linkage backcross intercross Resume Puissance de 2 plans d experience pour détecter une liaison génétique entre un locus marqueur et un locus influengant un caractère quantitatif dans une population en segregation. Cet article étudie la puissance statistique de 2 plans d experience rétrocroisement et intercroisement de F pour détecter une liaison génétique entre un gene marqueur et un locus de caractère quantitatif QTL dans des families dérivées d une population en segregation. Des formules sont établies pour exprimer la puissance en fonc-tion du taux de recombinaison r entre les genes des propriétés génétiques du caractère quantitatif contrôlé .
