Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: A genetic analysis of variable number of tandem repeats (VNTR) polymorphism in the horse | Genet Sei Evol 1993 25 435-445 Elsevier INRA 435 Original article A genetic analysis of variable number of tandem repeats VNTR polymorphism in the horse G Guérin1 M Bertaud1 B Billoud1 JC Mériaux2 1 INRA Laboratoire de Génétique Biochimique 2 INRA Laboratoire des Groupes Sanguins 78352 Jouy-en-Josas Cedex France Received 3 December 1992 accepted 1 July 1993 Summary - Restriction fragment length polymorphism detected with the minisatellite probe Jeffreys et al 1985 was analysed in 3 horse families of paternal half-sibs and in a sample of stallions from 4 breeds. Among the bands detected on Hae III genomic DNA digests it was found that strongly hybridizing fragments behaved as alleles at 2 different loci. These 2 loci showing 7 and 3 detectable alleles were not closely linked to each other nor to informative blood groups and protein markers. No neo-mutation in allele length was observed at these 2 loci ill the 3 families. In the stallion sample 8 alleles were detected at the first locus and no differences were found between their frequencies in the 4 breeds. Heterozygosity and polymorphism information content PIC values estimated in the 4 breeds show that the Thoroughbred is the least variable breed and the Arab the most. In the whole population the PIC values were and respectively. horse variable number of tandem repeats linkage genetic marker polymorphism Resume - Analyse génétique du polymorphisme du nombre variable de repetitions en tandem VNTR chez le cheval. Le polymorphisme de longueur de fragment de restriction détecté par la sonde minisatellite Jeffreys et al 1985 a été analyse chez le cheval dans trois families de demi-germains paternels et dans un échantillon d etalons de quatre races. Parmi toutes les bandes révélées à partir d ADN génomique digéré par Yiaelll les fragments donnant un signal intense se comportent comme des alleles ségrégeant à deux locus differents. Ceux-ci qui possèdent respectivement sept et trois alleles détectables
