Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Characterization of the ribonuclease activity on the skin surface | Genetic Vaccines and Therapy BioMed Central Research Open Access Characterization of the ribonuclease activity on the skin surface Jochen Probst1 Sonja Brechtel2 Birgit Scheel3 Ingmar Hoerr3 Gunther Jung4 Hans-Georg Rammensee1 and Steve Pascolo 1 Address Department of Immunology Institute for Cell Biology University of Tubingen Auf der Morgenstelle 15 72076 Tubingen Germany 2Microbial Genetics University of Tubingen Auf der Morgenstelle 28 72076 Tubingen Germany 3Cure Vac GmbH Paul Ehrlich 72076 Tubingen Germany and 4Institute for Organic Chemistry University of Tubingen Auf der Morgenstelle 18 72076 Tubingen Germany Email Jochen Probst - Sonja Brechtel - SonjaBrechtel@ Birgit Scheel - sp@ Ingmar Hoerr - ih@ Gunther Jung - Hans-Georg Rammensee - rammensee@ Steve Pascolo - Corresponding author Published 29 May 2006 Received 28 February 2006 Genetic Vaccines and Therapy 2006 4 4 doi 186 1479-0556-4-4 Accepted 29 May 2006 This article is available from http content 4 1 4 2006 Probst et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The rapid degradation of ribonucleic acids RNA by ubiquitous ribonucleases limits the efficacy of new therapies based on RNA molecules. Therefore our aim was to characterize the natural ribonuclease activities on the skin and in blood plasma . at sites where many drugs in development are applied. On the skin surfaces of Homo sapiens and Mus musculus we observed dominant pyrimidine-specific ribonuclease activity. This activity is not prevented by a cap structure at the 5 -end of messenger RNA mRNA and is .
