Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Transduction of the rat brain by Bovine Herpesvirus 4 | Genetic Vaccines and Therapy BioMed Central Open Access Transduction of the rat brain by Bovine Herpesvirus 4 Marco Redaelli1 2 Andrea Cavaggioni1 Carla Mucignat-Caretta1 2 Sandro Cavirani3 Antonio Caretta4 and Gaetano Donofrio 3 Address Department of Human Anatomy and Physiology University of Padova 35131 Padova Italy 2Department of Neuroscience University of Padova 35131 Padova Italy 3Department of Animal Health University of Parma 43100 Parma Italy and 4Department of Pharmaceutical Sciences University of Parma 43100 Parma Italy Email Marco Redaelli - Andrea Cavaggioni - Carla Mucignat- Caretta - Sandro Cavirani - Antonio Caretta - Gaetano Donofrio - Corresponding author Published 12 February 2008 Received 30 October 2007 J n I I 11- m M- r Accepted 12 February 2008 Genetic Vaccines and Therapy 2008 6 6 doi l479-0556-6-6 This article is available from http content 6 1 6 2008 Redaelli et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Bovine herpesvirus 4 BoHV-4 is a gamma-herpesvirus with no clear disease association. A recombinant BoHV-4 BoHV-4EGFPATK expressing Green Fluorescent Protein EGFP was successfully used to infect F98 rat glioma cells. BoHV-4EGFPATK was injected into the lateral ventricle of the rat brain. Histology and immunohistochemistry showed that ependymal and rostral migratory stream cells were transduced while neurons were not. Clinical scores evaluated for 90 days indicated that the virus was non neuropathogenic suggesting this virus is a .
