Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The use of fixed effect models and mixed models to estimate single gene associated effects on polygenic traits | 407 Genet Sei Evol 1991 23 407-419 Elsevier INRA Original article The use of fixed effect models and mixed models to estimate single gene associated effects on polygenic traits HB Bentsen G Klemetsdal Agricultural University of Norway Department of Animal Science N-l 32 Ẩs Norway Received 8 March 1989 accepted 23 July 1991 Summary - Single gene associated effects on polygenic traits may often be confounded with the effects of a non-random genetic relationship between individuals sharing a particular allele of the investigated gene. Two different statistical models are suggested to separate the single gene associated effects from the remaining additive genotype a fixed effect model with ancestor variables and a mixed model with random effects of the additive genotypes of the individual animals individual animal model . The use of the models is illustrated by an example from an experiment with the chicken major histocompatibility complex MHC gene region. single gene effects fixed effect model animal model chicken major histocompatibility complex Resume L utilisation des modèles à effets fixes et des modèles mixtes pour estimer des effets de genes individuels sur des caractères polygéniques. Des effets de genes individuels sur des caractères polygéniques sont souvent confondus avec des effets d une relation génétique non aléatoire entre individus partageant un allèle étudié. Deux modèles statistiques differents sont proposes pour séparer les effets associés au gene unique du genotype additif restant un modèle à effets fixes représentant les contributions des ancêtres et un modèle à effets aléatoires des genotypes additifs individuels modèle individuel animal . L emploi des modèles est illustré par une experience impliquant la region génique du complexe d histocompatibilite chez la poule. effet de gène individuel modèle à effets fixes modèle animal poule complexe majeur d histocompatibilite Correspondence and reprints HB Bentsen Institute of Aquaculture Research .
