Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The transcriptional program underlying the physiology of clostridial sporulation. | Research Open Access The transcriptional program underlying the physiology of clostridial sporulation Shawn W Jones Carlos J Paredes Bryan Tracy Nathan Cheng Ryan Sillers Ryan S Sengern and Eleftherios T Papoutsakisn Addresses Department of Chemical and Biological Engineering Northwestern University Sheridan Road Evanston IL 60208-3120 USA. Department of Chemical Engineering University of Delaware Academy Street Newark DE 19716 USA. Delaware Biotechnology Institute University of Delaware Innovation Way Newark DE 19711 USA. Current address Cobalt Biofuels Clyde Avenue Mountain View CA 94043 USA. Current address The Zitter Group New Montgomery Street San Francisco CA 94105 USA. Correspondence Eleftherios T Papoutsakis. Email epaps@ Published 16 July 2008 Genome Biology 2008 9 R1 14 doi gb-2008-9-7-r1 14 The electronic version of this article is the complete one and can be found online at http 2008 9 7 R114 Received 5 March 2008 Revised 6 June 2008 Accepted 16 July 2008 2008 Jones et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Clostridia are ancient soil organisms of major importance to human and animal health and physiology cellulose degradation and the production of biofuels from renewable resources. Elucidation of their sporulation program is critical for understanding important clostridial programs pertaining to their physiology and their industrial or environmental applications. Results Using a sensitive DNA-microarray platform and 25 sampling timepoints we reveal the genome-scale transcriptional basis of the Clostridium acetobutylicum sporulation program carried deep into stationary phase. A significant fraction of the genes displayed temporal expression in .
