Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Rapid identification of PAX2/5/8 direct downstream targets in the otic vesicle by combinatorial use of bioinformatics tools. | Research Open Access Rapid identification of PAX2 5 8 direct downstream targets in the otic vesicle by combinatorial use of bioinformatics tools Mirana Ramialison Baubak BajoghlT Narges AghaallaeH Laurence Ettwiller Sylvain Gaudan Beate Wittbrodt Thomas Czerny and Joachim Wittbrodt Addresses Developmental Biology Unit European Molecular Biology Laboratory Meyerhofstrasse 1 69117-Heidelberg Germany. Institute of Animal Breeding and Genetics University of Veterinary Medicine Veterinarplatz 1 A-1210 Vienna Austria. European Bioinformatics Institute Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SD UK. University of Applied Sciences FH Campus Wien Viehmarktgasse 2A 1030 Vienna Austria. Current Address Max-Planck Institute of Immunbiology Stubeweg 51 79108-Freiburg Germany. Correspondence Joachim Wittbrodt. Email Published I October 2008 Genome Biology 2008 9 RI45 doi gb-2008-9- I0-r I45 The electronic version of this article is the complete one and can be found online at http 2008 9 I0 RI45 Received II September 2008 Revised 29 September 2008 Accepted I October 2008 2008 Ramialison et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The pax2 5 8 genes belonging to the PAX family of transcription factors are key developmental regulators that are involved in the patterning of various embryonic tissues. More particularly their function in inner ear specification has been widely described. However little is known about the direct downstream targets and so far no global approaches have been performed to identify these target genes in this particular tissue. Results Here we present an original bioinformatics pipeline composed of comparative .
