Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Characterization of the differentially methylated region of the Impact gene that exhibits Glires-specific imprinting. | Research Open Access Characterization of the differentially methylated region of the Impact gene that exhibits Glires-specific imprinting Kohji Okamiira Richard F Wintle and Stephen W Scherer Addresses The Centre for Applied Genomics Program in Genetics and Genome Biology The Hospital for Sick Children MaRS Centre TMDT 101 College Street Toronto Ontario M5G 1L7 Canada. Department of Molecular and Medical Genetics University of Toronto Toronto Ontario M5S 1A8 Canada. Current address Human Genome Centre Institute of Medical Science University of Tokyo 4-6-1 Shirokanedai Minato Ward Tokyo 108-8639 Japan. Correspondence Kohji Okamura. Email o-cuniculus@ Published 13 November 2008 Genome Biology 2008 9 R160 doi gb-2008-9- 11-r160 The electronic version of this article is the complete one and can be found online at http 2008 9 11 R160 Received 8 October 2008 Accepted 13 November 2008 2008 Okamura et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Imprinted genes are exclusively expressed from one of the two parental alleles in a parent-of-origin-specific manner. In mammals nearly 100 genes are documented to be imprinted. To understand the mechanism behind this gene regulation and to identify novel imprinted genes common features of DNA sequences have been analyzed however the general features required for genomic imprinting have not yet been identified possibly due to variability in underlying molecular mechanisms from locus to locus. Results We performed a thorough comparative genomic analysis of a single locus Impact which is imprinted only in Glires rodents and lagomorphs . The fact that Glires and primates diverged from each other as recent as 70 million years ago .
