Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Identifying protein-coding genes in genomic sequences. | Review Identifying protein-coding genes in genomic sequences Jennifer Harrow Alinda Nagy Alexandre Reymond Tyler Alioto Laszlo Patthy Stylianos E Antonarakis and Roderic Guigỏs Addresses Wellcome Trust Sanger Institute Wellcome Trust Campus Hinxton Cambridge CB10 1SA UK. Institute of Enzymology Biological Research Center Hungarian Academy of Sciences H-1113 Budapest Hungary. Center for Integrative Genomics Genopode Building University of Lausanne CH-1015 Lausanne Switzerland. Centre de Regulaciỏ Genòmica Institut Municipal d Investigaciỏ Mèdica Universitat Pompeu Fabra E-08003 Barcelona Catalonia Spain. Department of Genetic Medicine and Development University of Geneva Medical School and University Hospitals of Geneva Geneva 1211 Switzerland. Correspondence Roderic Guigỏ Email Published 30 January 2009 GenomeBiology 2009 10 201 doi gb-2009-l0-l-20l The electronic version of this article is the complete one and can be found online at http 2009 l0 l 20l 2009 BioMed Central Ltd Abstract The vast majority of the biology of a newly sequenced genome is inferred from the set of encoded proteins. Predicting this set is therefore invariably the first step after the completion of the genome DNA sequence. Here we review the main computational pipelines used to generate the human reference protein-coding gene sets. The genome sequence is an organism s blueprint the set of instructions dictating its biological traits. The unfolding of these instructions is initiated by the transcription of the DNA into RNA sequences. According to the standard model the majority of RNA sequences originate from proteincoding genes that is they are processed into messenger RNAs mRNAs which after their export to the cytosol are translated into proteins. While the importance of noncoding RNAs has come to the fore over the past ten years 1-5 proteins are still assumed to be the main functional and structural players in the cell. The delineation of the .
