Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The secret(ion) life of worms. | Minireview The secret ion life of worms David McK Bird and Charles H Opperman Address Center for the Biology of Nematode Parasitism North Carolina State University Raleigh NC 27695 USA. Correspondence David McK Bird. Email david_bird@ Published 28 January 2009 Genome Biology 2009 10 205 doi gb-2009-10-1-205 The electronic version of this article is the complete one and can be found online at http 2009 10 1 205 2009 BioMed Central Ltd Abstract Tandem mass spectrographic analysis of the secreted proteins of plant- and human-parasitic nematodes reveals molecular similarities that reflect the shared need to counter host defenses. Nematodes are the most important parasites of plants and animals worldwide contributing to human misery both through direct infection and through losses to livestock and agricultural crops. Driven largely by genome projects several parasitic nematode species have emerged as model organisms. These include Brugia malayi 1 a filarial nematode parasitizing the lymphatic system and causing elephantiasis in humans and root-knot nematodes of the genus Meloidogyne 2 3 which attack essentially all crop plants. How these parasites are able to evade host defense responses and establish the intimate association within the host necessary for feeding and subsequent reproduction has been a key question over the past 50 years 4 . It is believed that secretions from the nematode are crucial in invasion and establishment in the host and the advent of molecular and genomic technologies has allowed researchers to catalog and describe a large set of secreted proteins from plant-parasitic and human animal-parasitic nematodes. Recently the power of tandem mass spectrometry coupled with liquid chromatography LC-MS-MS has been used to experimentally identify peptides defining the parasites secreted proteins the secretome and two recent publications demonstrate the tremendous progress that has been made. Bellafiore et al. 5 describe .
