Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Analysis of the platypus genome suggests a transposon origin for mammalian imprinting. | Open Access Analysis of the platypus genome suggests a transposon origin for mammalian imprinting Andrew J PaskH Anthony T PapenfussH Eleanor I Ager Kaighin A McColl Terence P Speed and Marilyn B Renfree Addresses Department of Zoology The University of Melbourne Melbourne Victoria 3010 Australia. Department of Molecular and Cellular Biology The University of Connecticut Storrs CT 06269 USA. Bioinformatics Division The Walter and Eliza Hall Institute 1G Royal Parade Parkville Victoria 3050 Australia. H These authors contributed equally to this work. Correspondence Andrew J Pask. Email Published 2 January 2009 Genome Biology 2009 10 R1 doi gb-2009-l0-l-rl The electronic version of this article is the complete one and can be found online at http 2009 l0 l Rl Received 2l November 2008 Accepted 2 January 2009 2009 Pask et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Genomic imprinting is an epigenetic phenomenon that results in monoallelic gene expression. Many hypotheses have been advanced to explain why genomic imprinting evolved in mammals but few have examined how it arose. The host defence hypothesis suggests that imprinting evolved from existing mechanisms within the cell that act to silence foreign DNA elements that insert into the genome. However the changes to the mammalian genome that accompanied the evolution of imprinting have been hard to define due to the absence of large scale genomic resources between all extant classes. The recent release of the platypus genome has provided the first opportunity to perform comparisons between prototherian monotreme which appear to lack imprinting and therian marsupial and eutherian which have imprinting
