Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Characterization of taxonomically restricted genes in a phylum-restricted cell type. | Open Access Researc h Characterization of taxonomically restricted genes in a phylum-restricted cell type Sabine MildeH Georg HemmrichH Friederike Anton-Erxleben Konstantin Khalturin Jorg Wittlieb and Thomas CG Bosch Address Zoological Institute Christian-Albrechts-University Kiel Olshausenstr. 40 24098 Kiel Germany. H These authors contributed equally to this work. Correspondence Thomas CG Bosch. Email tbosch@ Received 9 October 2008 Revised ll December 2008 Accepted 22 January 2009 Published 22 January 2009 Genome Biology 2009 10 R8 doi gb-2009-l 0-l-r8 The electronic version of this article is the complete one and can be found online at http 2009 l0 l R8 2009 Milde et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Despite decades of research the molecular mechanisms responsible for the evolution of morphological diversity remain poorly understood. While current models assume that species-specific morphologies are governed by differential use of conserved genetic regulatory circuits it is debated whether non-conserved taxonomically restricted genes are also involved in making taxonomically relevant structures. The genomic resources available in Hydra a member of the early branching animal phylum Cnidaria provide a unique opportunity to study the molecular evolution of morphological novelties such as the nematocyte a cell type characteristic of and unique to Cnidaria. Results We have identified nematocyte-specific genes by suppression subtractive hybridization and find that a considerable portion has no homologues to any sequences in animals outside Hydra. By analyzing the transcripts of these taxonomically restricted genes and mining of the Hydra .
