Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Coding region structural heterogeneity and turnover of transcription start sites contribute to divergence in expression between duplicate genes. | Open Access Coding region structural heterogeneity and turnover of transcription start sites contribute to divergence in expression between duplicate genes Chungoo Park and Kateryna D Makova Address Center for Comparative Genomics and Bioinformatics Department of Biology The Pennsylvania State University University Park PA 16802 USA. Correspondence Kateryna D Makova. Email kdm16@ Published 28 January 2009 Genome Biology 2009 10 R10 doi gb-2009- 10-1-r10 The electronic version of this article is the complete one and can be found online at http 2009 10 1 R10 Received 11 October 2008 Revised 24 December 2008 Accepted 28 January 2009 2009 Park and Makova licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Gene expression divergence is one manifestation of functional differences between duplicate genes. Although rapid accumulation of expression divergence between duplicate gene copies has been observed the driving mechanisms behind this phenomenon have not been explored in detail. Results We examine which factors influence expression divergence between human duplicate genes utilizing the latest genome-wide data sets. We conclude that the turnover of transcription start sites between duplicate genes occurs rapidly after gene duplication and that gene pairs with shared transcription start sites have significantly higher expression similarity than those without shared transcription start sites. Moreover we find that most 55 duplicate gene pairs do not retain the same coding sequence structure between the two duplicate copies and this also contributes to divergence in their expression. Furthermore the proportion of aligned sequences in c s-regulatory regions between the two copies is
