Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Reality check for malaria | Minireview Reality check for malaria proteomics Robert E Sinden Address The Malaria Centre Department of Life Sciences Imperial College London SW7 2AZ UK. Email Published 26 February 2009 GenomeBiology 2009 10 211 doi gb-2009-10-2-211 The electronic version of this article is the complete one and can be found online at http 2009 10 2 211 2009 BioMed Central Ltd Abstract New studies highlight the wide diversity of post-translational protein modifications in the intra-erythrocytic stages of the malaria parasite raising new avenues for inquiry. Now is an exciting time to be in malaria research. The science is moving at an ever faster pace and the malaria research community has been challenged by Bill and Melinda Gates to re-engage with the ambitious concept of global eradication of malaria. Fundamental to any new efforts to attack the parasite Plasmodium or its mosquito vectors Anopheles species is the need to understand the regulation and molecular organization of parasite development throughout its complex life cycle Figure 1 . A new study by Foth et al. 1 published in Genome Biology adds a significant new dimension to this understanding by using methods that detect and delineate a diversity of post-translational modifications to proteins in the asexual stages of the parasite infecting the red blood cells of its human host the stage that causes the debilitating clinical symptoms of malaria. Just-in-time regulation and its exceptions The sequencing of the genome of Plasmodium falciparum in 2002 made possible high-throughput global analysis of the transcriptome 2-5 . Interpreted in the light of the limited previous work on the expression of individual proteins these transcriptome analyses suggested that a significant fraction of the genome is regulated in a just-in-time manner that is immediate translation implicitly of bioactive proteins of newly synthesized transcripts 3 . The first proteomic studies emerged soon .
