Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virus. | Open Access Research The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virus Rachel Brower-Sinning Donald M Carter Corey J Crevar Elodie Ghedin Ted M Ross and Panayiotis V Benos Addresses Department of Computational Biology School of Medicine University of Pittsburgh Fifth Avenue Pittsburgh PA 15260 USA. Center for Vaccine Research University of Pittsburgh Fifth Avenue Pittsburgh PA 15260 USA. Department of Medicine School of Medicine University of Pittsburgh Fifth Avenue Pittsburgh PA 15261 USA. Department of Microbiology and Molecular Genetics School of Medicine University of Pittsburgh Lothrop Street Pittsburgh PA 15261 USA. Department of Biomedical Informatics School of Medicine University of Pittsburgh Meyran Avenue Pittsburgh PA 15260 USA. Correspondence Panayiotis V Benos. Email benos@ Published 12 February 2009 Genome Biology 2009 10 R18 doi gb-2009- l0-2-rl8 The electronic version of this article is the complete one and can be found online at http 2009 l0 2 Rl8 Received 4 December 2008 Revised 29 January 2009 Accepted l2 February 2009 2009 Brower-Sinning et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The influenza A virus genome is composed of eight single-stranded RNA segments of negative polarity. Although the hemagglutinin and neuraminidase genes are known to play a key role in host adaptation the polymerase genes which encode the polymerase segments PB2 PBl PA and the nucleoprotein gene are also important for the efficient propagation of the virus in the host and for its adaptation to new hosts. Current efforts to understand the host-specificity of the virus have largely focused on the amino acid .
