Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Yale University, Whitney Ave, New Haven, CT 06520, USA. | Software Open Access PEMer. a computational framework with simulation-based error models for inferring genomic structural variants from massive paired-end sequencing data Jan O Korbel Alexej Abyzov Xinmeng Jasmine Mu Nicholas Carriero Philip Cayting Zhengdong Zhang Michael Snyder and Mark B Gerstein Y Addresses Gene Expression Unit European Molecular Biology Laboratory EMBL Meyerhofstr. Heidelberg 69117 Germany. EMBL Outstation Hinxton EMBL-European Bioinformatics Institute EMBL-EBI Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SA UK. Molecular Biophysics and Biochemistry Department Yale University Whitney Ave New Haven CT 06520 USA. Department of Molecular Cellular and Developmental Biology Yale University Whitney Ave New Haven CT 06520 USA. Department of Computer Science Yale University Prospect Street New Haven CT 06511 USA. YProgram in Computational Biology and Bioinformatics Yale University Whitney Ave New Haven CT 06520 USA. Correspondence Jan O Korbel. Email korbel@ Published 23 February 2009 Genome Biology 2009 10 R23 doi gb-2009- 10-2-r23 The electronic version of this article is the complete one and can be found online at http 2009 10 2 R23 Received 1 September 2008 Revised 22 December 2008 Accepted 23 February 2009 2009 Korbel et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Personal-genomics endeavors such as the 1000 Genomes project are generating maps of genomic structural variants by analyzing ends of massively sequenced genome fragments. To process these we developed Paired-End Mapper PEMer http pemer . This comprises an analysis pipeline compatible with several next-generation sequencing platforms simulation-based error models .
