Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Building bridges from ‘omics’ to cell biology. | Meeting report Building bridges from omics to cell biology Brian Cox Address The Hospital for Sick Children Research Institute Program in Stem Cell and Developmental Biology 101 College Street Toronto Ontario Canada M5G 1L7. Email Published 10 March 2009 Genome Biology 2009 10 305 doi gb-2009-10-3-305 The electronic version of this article is the complete one and can be found online at http 2009 10 3 305 2009 BioMed Central Ltd A report from the Keystone Symposium on Molecular and Cellular Biology Omics Meets Cell Biology Breckenridge Colorado 25-30 January 2009. A recent meeting in the Keystone series focused on the convergence of two fields large-scale biology omics defined as anything with an omic ending - genomics proteomics metabolomics and so on and cell biology including yeast mammalian tissue culture and animal models such as Drosophila Caenorhabditis elegans and mouse. Ruedi Aebersold Institute for Molecular Systems Biology Zurich Switzerland explained the concept as two groups of researchers - the cell biologists who create islands of knowledge and the omicists who try to connect these islands together. Screens based on RNA interference RNAi are now widely used to uncover new members of signaling pathways and to assess gene function. An interesting extension of the image analysis typically used in cell-based RNAi screens was presented by Lucas Pelkmans Institute for Molecular Systems Biology Zurich Switzerland for screens designed to uncover cellular factors affecting viral infectivity. He showed that cell-based screens can be subject to a high degree of variability potentially due to heterogeneity in the cell population. But by controlling for cell morphology and density biases in viral infection that had previously confounded the comparison between normal and RNAi-treated cells Pelkmans and colleagues were able to identify Dyrk kinases as affecting the infectivity of a wide range of viruses. Other screens .
