Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: DISTILLER: a data integration framework to reveal condition dependency of complex regulons in. | Open Access Method DISTILLER a data integration framework to reveal condition dependency of complex regulons in Escherichia coli Karen Lemmens Tijl De Bie Thomas Dhollander Sigrid C De Keersmaecker Inge M Thijs Geert Schoofs Ami De Weerdt Bart De Moor Jos Vanderleyden Julio Collado-Vides Kristof Engelen and Kathleen Marchal Addresses Department of Electrical engineering Katholieke Universiteit Leuven Kasteelpark Arenberg 10 3001 Leuven Belgium. Department of Engineering Mathematics University of Bristol Bristol BS8 1TR UK. OKP Research Group Katholieke Universiteit Leuven Leuven 3000 Belgium. Department of Microbial and Molecular systems Katholieke Universiteit Leuven Kasteelpark Arenberg 20 3001 Leuven Belgium. Centro de Ciencias Genómicas Universidad Nacional Autónoma de Mexico Cuernavaca AP 565-A Mexico. Correspondence Kathleen Marchal. Email Published 6 March 2009 Genome Biology 2009 10 R27 doi gb-2009- 10-3-r27 The electronic version of this article is the complete one and can be found online at http 2009 10 3 R27 Received 16 October 2008 Revised 15 January 2009 Accepted 6 March 2009 2009 Lemmens et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We present DISTILLER a data integration framework for the inference of transcriptional module networks. Experimental validation of predicted targets for the well-studied fumarate nitrate reductase regulator showed the effectiveness of our approach in Escherichia coli. In addition the condition dependency and modularity of the inferred transcriptional network was studied. Surprisingly the level of regulatory complexity seemed lower than that which would be expected from RegulonDB indicating that complex .
