Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Transcriptional features of genomic regulatory blocks. | Researc h Open Access Transcriptional features of genomic regulatory blocks Altuna Akalin David Fredman Erik Arner Xianjun Dong Jan Christian Bryne Harukazu Suzukh Carsten O Daub Yoshihide Hayashizakk and Boris Lenhard Addresses Computational Biology Unit Bergen Center for Computational Science and Sars Centre for Marine Molecular Biology University of Bergen 5008 Bergen Norway. tRIKEN Omics Science Center RIKEN Yokohama Institute 1-7-22 Suehiro-cho Tsurumi-ku Yokohama Kanagawa Japan. Current address Department for Molecular Evolution and Development Centre for Organismal Systems Biology Faculty of Life Sciences University of Vienna Althanstrasse 1090 Wien Austria. Correspondence Boris Lenhard. Email Published 19 April 2009 Genome Biology 2009 10 R38 doi gb-2009- 10-4-r38 The electronic version of this article is the complete one and can be found online at http 2009 10 4 R38 Received 31 October 2008 Revised 10 February 2009 Accepted 19 April 2009 2009 Akalin et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Genomic regulatory blocks GRBs are chromosomal regions spanned by highly conserved non-coding elements HCNEs most of which serve as regulatory inputs of one target gene in the region. The target genes are most often transcription factors involved in embryonic development and differentiation. GRBs often contain extensive gene deserts as well as additional bystander genes intertwined with HCNEs but whose expression and function are unrelated to those of the target gene. The tight regulation of target genes complex arrangement of regulatory inputs and the differential responsiveness of genes in the region call for the examination of fundamental .
