Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure. | Open Access Method Choosing the right path enhancement of biologically relevant sets of genes or proteins using pathway structure Reuben Thomas Julia M Gohlke Geffrey F Stopper Frederick M Parham and Christopher J Portier Addresses Environmental Systems Biology Group Laboratory of Molecular Toxicology National Institute of Environmental Health Sciences RTP NC 27709 USA. Department of Biology Sacred Heart University Fairfield CT 06825 USA. n These authors contributed equally to this work. Correspondence Christopher J Portier. Email portier@ Published 24 April 2009 Genome Biology 2009 10 R44 doi gb-2009- 10-4-r44 The electronic version of this article is the complete one and can be found online at http 2009 10 4 R44 Received 21 November 2008 Revised 19 March 2009 Accepted 24 April 2009 2009 Thomas et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract A method is proposed that finds enriched pathways relevant to a studied condition using the measured molecular data and also the structural information of the pathway viewed as a network of nodes and edges. Tests are performed using simulated data and genomic data sets and the method is compared to two existing approaches. The analysis provided demonstrates the method proposed is very competitive with the current approaches and also provides biologically relevant results. Background Data on the molecular scale obtained under different sampling conditions are becoming increasingly available from platforms like DNA microarrays. Generally the reason for obtaining molecular data is to use these data to understand the behavior of a system under insult or during perturbations such as occurs following exposure to certain toxicants or when
