Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: microRNAs mature with help from cancer biology. | X Genome Biology Meeting report microRNAs mature with help from cancer biology Zain Paroo and Alexander Pertsemlidis t Addresses Department of Biochemistry and Department of Internal Medicine and Harold C Simmons Comprehensive Cancer Center UT Southwestern Medical Center Dallas TX 75930-8591 USA. Correspondence Alexander Pertsemlidis. Email Abstract A report of the Keystone Symposium on Molecular and Cellular Biology MicroRNA and Cancer Keystone Colorado USA 10-15 June 2009. A recent meeting in the series of Keystone Symposia focused on the intersection of microRNA miRNA and cancer biology. The meeting was characterized by the traditional hallmarks of Keystone Symposia a defined scientific focus a single thread and an emphasis on presentation of unpublished results. The breadth of topics covered reflected the rapid maturation of the field. Here we highlight three major themes that ran through the plenary sessions. Non-coding RNA variation Our understanding of the importance of non-coding RNA ncRNA biology has evolved rapidly. John Mattick University of Queensland Brisbane Australia reminded us that organismal complexity scales with the non-coding rather than the coding genome. These are still early days for the field with new classes of ncRNA such as transcription initiation RNA tiRNA and new functions for understudied ncRNA such as small nucleolar RNA snoRNA on the horizon. Highlighting important advances in our understanding of molecular biology Mattick discussed dissociated expression of 3 untranslated regions UTRs from their coding sequences which would enable genetic information to be transmitted in trans. Joel Neilson Massachusetts Institute of Technology Cambridge USA later picked up this thread and demonstrated dynamic regulation of 3 UTR expression. He described work on primary lymphocytes in which cellular proliferation was associated with reduced 3 UTR length findings that parallel the decreased miRNA expression
