Báo cáo y học: "Defining and targeting transcription factors in cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Defining and targeting transcription factors in cancer. | X Genome Biology Meeting report Defining and targeting transcription factors in cancer Aisling M Redmond and Jason S Carrollt Addresses Endocrine Oncology Research Group Department of Surgery Royal College of Surgeons in Ireland St Stephens Green Dublin 2 Ireland. tCancer Research UK Cambridge Research Institute Robinson Way Cambridge CB2 ORE UK. Correspondence Jason S Carroll. Email Abstract A report from the Keystone Symposium on Molecular and Cellular Biology Deregulation of transcription in cancer controlling cell fate decisions Killarney Ireland 21-26 July 2009. This Keystone meeting focused on mechanisms of transcriptional regulation the effects of transcriptional deregulation and the consequences on cancer and the possibilities for inhibiting transcription factors as potential therapeutic targets. Greg Verdine Harvard University Cambridge USA suggested that until now only 20 of the genome was targetable with drugs druggable . Transcription factors have traditionally been considered too difficult to target but with increased understanding of transcription factor biology and technological advances targeting them is becoming a realistic option. The role of polycomb complexes in regulating transcriptional activity was an important theme to the meeting. Kristian Helin University of Copenhagen Denmark summarized the role of polycomb repressor complexes involving EZH2 in controlling senescence in particular their role in the regulation of the p16INK4A and p14ARF tumor suppressor proteins. Competitive binding between polycomb repressor complexes and the histone demethy-lase JMJD3 determines transcriptional activity suggesting that JMJD3 can act as a tumor suppressor. Maarten Van Lohuizen Netherlands Cancer Institute Amsterdam The Netherlands presented work on BMI1 a member of the polycomb repressor complex PRC1 which is crucial in the maintenance of adult stem cells. Loss of BMI1 in mouse models causes a dramatic reduction in .

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