Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: New levels of sophistication in the transcriptional landscape of bacteria. | X Genome Biology Minireview New levels of sophistication in the transcriptional landscape of bacteria Arnoud HM van Vliet and Brendan W Wrent Addresses Institute of Food Research Colney Lane Norwich NR4 7UA UK. Department of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine Keppel Street London WC1E 7HT UK. Correspondence Brendan W Wren. Email Abstract An extra layer of complexity in the regulation of gene expression in bacteria is now apparent through previously unanticipated roles of noncoding and antisense RNAs. Bacteria are the great survivors on planet Earth where they can adapt and flourish in harsh environments ranging from deep-sea vents to acidic mine shafts. A feature of many bacteria particularly pathogenic bacteria is their ability to adapt and thrive in multiple environments which provides them with a competitive advantage. For example the facultative intracellular pathogen Listeria monocytogenes happily survives in the ambient environment as a saprophyte but on occasions it has an inherent capacity to turn nasty and cause brain and materno-fetal infections in humans 1 . This requires the bacterium to switch genes on and off as it traverses different environments ranging from a saprophytic lifestyle to the gut lumen after ingestion to invasion of epithelial cells and intracellular survival. The key to the survivalist success of pathogens is their ability to coordinate redirect and fine-tune their genetic repertoire as and when required. Traditionally transcriptional reshaping in bacteria has been considered to be controlled by a hierarchical network of interconnected global transcriptional regulators such as sigma factors and one- and two-component regulatory systems 2 . In the past decade it has become apparent that the various forms of noncoding regulatory RNA previously considered as intergenic junk play important roles in the global regulation of cellular functions and may represent connecting
