Weiss đã chứng minh làm sáng của lentigines và các khu vực hyperpigmented khác trên mặt và cánh tay của 30 đối tượng áp dụng 0,1 kem tretinoin% mỗi ngày so với xe trong 4 tháng [67]. Là một phần mở rộng của phiên tòa đó, Ellis đã chứng minh cải tiến hơn nữa trong tăng sắc tố cũng như các thông số khác của ánh nắng trong khoảng thời gian 6 tháng | 46 Susan C. Taylor 3 Table . Treatment of pigmentary characteristics of photoaging in Asian African American and Caucasian skin Treatment modality Asian African American Caucasian Sunscreen Antioxidants Retinoids Hydroquinones Chemical peels Microdermabrasion Cryotherapy - Laser Intense pulse light the three retinoids available in the United States tretinoin adapalene and tazarotene effectively lighten pigmentary abnormalities associated with photoaging. Weiss demonstrated lightening of lentigines and other hyperpigmented areas on the face and forearms of 30 subjects who applied tretinoin cream daily compared with vehicle for 4 months 67 . As an extension of that trial Ellis demonstrated further improvement in hyperpigmentation as well as the other parameters of photoaging over a 6-month period with topical tretinoin applied daily to the face and forearm 68 . Rafal evaluated the efficacy of topical tretinoin in the treatment of lentigines associated with photoaging 69 . Tretinoin in a concentration was applied to the faces of 58 subjects in this 10month study. Clinical lightening of solar lenti-gines was noted in 83 of the treated facial lesions compared with 29 of controls. Histological analysis revealed a 35 decrease in epidermal pigmentation in the treated group compared with a 34 increase in the vehicle-treated group. Griffiths examined the efficacy of tretinoin cream for 4 weeks in 45 Asians with hyperpigmented lesions on the face and hands 70 . Each subject had at least four lentigines on the face and or hands. Hyperpigmented lesions were lighter or much lighter in 90 of the patients receiving tretinoin compared with 33 of controls. Histology demonstrated a 41 decrease in epidermal pigmentation in the treated group compared with a 37 increase in the control group. There was a statistically significant correlation between decrease in histologic epidermal pigment and clinical lightening of the pigmented lesions. In a primarily African American .
