Rất khó để rút ra kết luận về vai trò của antifungals từ những nghiên cứu nhỏ và khác nhau. Không có bằng chứng hiện tại để hỗ trợ việc sử dụng thường xuyên trong điều trị eczema dị ứng lâm sàng nhiễm. | Evidence-based Dermatology Comment and implications There is no evidence to support a benefit from topical steroid antiseptic combinations over topical steroid alone. How effective are topical antifungals Effectiveness One RCT evaluated a combination of topical steroid antibiotic antifungal versus topical steroid antiseptic in clinically infected atopic eczema Table .18 Both combinations produced a highly significant reduction in clinical scores and bacterial counts with no significant difference between Comment and implications It is difficult to draw conclusions about the role of antifungals from these small and disparate studies. There is no current evidence to support their routine use in the treatment of clinically infected atopic eczema. How useful are antiseptics agents in clinically infected atopic eczema This section includes antiseptic emollients bath additives and other antiseptic treatments. Efficacy There are no RCTs of antiseptics in clinically infected atopic eczema. Non-infected eczema We located two further RCTs evaluating topical antifungals in non-clinically infected atopic 21 The first small study compared topical steroid antibiotic antifungal against topical steroid antibiotic and showed a significant improvement in the four patients treated with 0-1 triamcinolone acetonide 0-35 neomycin undecylenic acid compared with the six receiving the same steroid antibiotic combination but without undecylenic In the second study Broberg et attempted to evaluate the role of antifungals in atopic eczema of the head and neck area. All patients received oral antibiotics followed by randomisation to either miconazole-hydrocortisone cream plus ketoconazole shampoo or hydrocortisone cream plus placebo shampoo. There was no significant difference between the groups in clinical Possible drawbacks Where side-effects were documented minor skin irritation and possible hypersensitivity reactions were seen in up to
