Trong số bốn bệnh nhân có tổn thương da, ba đã có ít nhất 60% hồi quy, và một đã hồi quy đầy đủ các tổn thương với methotrexate. Gedalia et trình bày kết quả của methotrexate, 10-15 mg / tuần, trong bảy bệnh nhân trẻ em với sarcoidosis. | Evidence-based Dermatology with methotrexate 10 mg week for 30 months. Of the four patients with skin lesions three had at least 60 regression and one had complete regression of lesions with methotrexate. Gedalia et presented the results of methotrexate 10-15 mg week in seven paediatric patients with sarcoidosis. Of the three patients with cutaneous lesions two had resolution of their skin findings with methotrexate. Mean dose of prednisone for all study participants was tapered from an average of 49 mg day to 7-3 mg day at 6 Lacher45 published the first case report of methotrexate for cutaneous sarcoidosis describing a patient in whom prednisone failed but who responded to a combination of prednisone 75 mg three times weekly and methotrexate 40 mg twice weekly. The dose of prednisone was eventually tapered and the patient maintained on methotrexate 7-5 mg twice weekly. Webster et al46 presented case reports on three patients who had improvement of their severe steroid-resistant cutaneous sarcoidosis with methotrexate 15-22-5 mg week. Henderson et presented a case report of a man with steroid-resistant laryngeal and cutaneous sarcoidosis who responded to methotrexate 10 mg week. Harms Complications of methotrexate therapy include bone marrow suppression nausea and vomiting hepatotoxicity and hypersensitivity Albertini et described a patient with severe systemic and ulcerative sarcoidosis who was started on methotrexate 25 mg per week. Although her ulcerative lesions initially regressed she soon developed anaemia leucopenia and elevated aspartate transaminase level necessitating the withdrawal of methotrexate. The patient subsequently died of her disease. Major toxic effects noted by Lower et al. were hepatotoxicity leucopenia and Comment implications for clinical practice Articles written to date describe experience with a total of 46 patients with cutaneous sarcoidosis treated with methotrexate of whom 39 had .
