Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Effect of including major gene information in mass selection: a stochastic simulation in a small population | Genet Sei Evol 1997 29 35-56 Elsevier INRA 35 Original article Effect of including major gene information in mass selection a stochastic simulation in a small population F Fournet JM Eisen ME Barbieri E Manfredi Station d amelioration génétique des animaux Institut national de la recherche agronomique 31320 Castanet-Tolosan France Received 5 December 1995 accepted 18 November 1996 Summary - A quantitative trait under the control of a major gene plus a finite number of genes with small effects was described using a stochastic model where number size and linkage between QTL may vary. Selection schemes defined by the selection criteria individual phenotype major genotype and combination of both sources of information the population size and the selection intensities in male and female paths were considered. Different genetic hypotheses were studied concerning the major gene effect the number of small quantitative loci and the linkage between genes. The ranking of the selection schemes over 30 generations was performed with the following criteria time taken for the fixation of the favourable A allele at the major locus and differences between the cumulated discounted gains obtained with each scheme. The interactions between the major gene and the flanking QTLs were also studied. The main result was that the inclusion of major gene information in selection schemes was mostly efficient in the medium and long term when the gene was rare and recessive and in the medium term when it was rare and additive essentially due to a rapid fixation of the favourable A allele and to a limited risk of losing it by genetic drift for a rare recessive gene. major gene I QTL selection Monte-Carlo Resume Inclusion de 1 information à un locus majeur en selection massale un modèle stochastique dans une petite population. Un caractère quantitatif sous le contrôle d un gene majeur et d un nombre fini de gènes à effets faibles est décrit à I aide d un modèle stochastique où le nombre de QTL et
