Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions. | Open Access Draft genome sequence of the Daphnia pathogen Octosporea bayeri insights into the gene content of a large microsporidian genome and a model for host-parasite interactions Nicolas Corradi Karen L Haag Jean-Franẹois Pombert Dieter EbertHt and Patrick J Keeling Addresses Canadian Institute for Advanced Research The Biodiversity Research Centre University of British Columbia University Boulevard Vancouver BC V6T 1Z4 Canada. Universitat Basel Zoologisches Institut Evolutionsbiologie Vesalgasse CH-4051 Basel Switzerland. Department of Genetics UFRGS Porto Alegre RS 91501-970 Brazil. H These authors contributed equally to this work. Correspondence Patrick J Keeling. Email pkeeling@ Published 6 October 2009 Genome Biology 2009 10 RI06 doi gb-2009-I0-I0-rI 06 The electronic version of this article is the complete one and can be found online at http 2009 10 10 R106 Received 9 July 2009 Revised 2 September 2009 Accepted 6 October 2009 2009 Corradi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The highly compacted genome of Encephalitozoon cuniculi placed the microsporidia in the spotlight encoding a mere 2 000 proteins and a highly reduced suite of biochemical pathways. This extreme level of reduction is not universal across the microsporidia with genomes known to vary up to sixfold in size suggesting that some genomes may harbor a gene content that is not as reduced as that of Enc. cuniculi. In this study we present an in-depth survey of the large genome of Octosporea bayeri a pathogen of Daphnia magna with an estimated genome size of 24 Mb in order to shed light on the organization and content of a large microsporidian genome. Results Using .
