Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Non-imprinted allele-specific DNA methylation on human autosomes. | Open Access Researc h Non-imprinted allele-specific DNA methylation on human autosomes Yingying Zhang Christian Rohde Richard Reinhardt Claudia Voelcker-Rehage and Albert Jeltsch Addresses School of Engineering and Science Jacobs University Bremen Campus Ring 1 D-28759 Bremen Germany. tMax Planck Institute for Molecular Genetics Ihnestrasse 63-73 D-14195 Berlin-Dahlem Germany. Jacobs Center on Lifelong Learning and Institutional Development Jacobs University Bremen Campus Ring 1 D-28759 Bremen Germany. Correspondence Albert Jeltsch. Email Published 3 December 2009 Genome Biology 2009 10 R138 doi gb-2009-10-12-r1 38 The electronic version of this article is the complete one and can be found online at http 2009 10 12 R138 Received 17 July 2009 Revised 23 October 2009 Accepted 3 December 2009 2009 Zhang et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Differential DNA methylation between alleles is well established in imprinted genes and the X chromosomes in females but has rarely been reported at non-imprinted loci on autosomes. Results We studied DNA methylation of cytosine-guanine dinucleotide CpG islands on chromosome 21 in leukocytes from several healthy individuals and observed novel cases of pronounced differential methylation of alleles. Allele-specific methylation affected complete CpG islands with methylation differences between alleles of up to 85 . The methylation differences between alleles were strongly correlated with the genotypes excluding a connection to imprinting. We show that allele-specific methylation can lead to allelic repression of the methylated gene copy. Based on our results allele-specific methylation is likely to .
