Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: XGAP: a uniform and extensible data model and software platform for genotype and phenotype experiments. | Swertz et al. Genome Biology 2010 11 R27 http 2010 11 3 R27 Genome Biology SOFTWARE Open Access XGAP a uniform and extensible data model and software platform for genotype and phenotype experiments Morris A Swertz1 2 3 K Joeri van der Velde1 2 Bruno M Tesson2 Richard A Scheltema2 Danny Arends1 2 S -7 s I S IT 2 rh I I I I A I K f- r 4 h ỉ I I 4 . l h ỉ I 5 D I I I c z z íỉ J I I6 I I I I r G hll z t r 4 I 4 . h ỉ I_I r r r I 7 Gonzalo Vera RUdi Alberts Martijn Dijkstra Paul Schofield Klaus SChughart John M Hancock Ch I zs c W J I x z3 1 F f A r I zs r Kz f F8 r s I J l I J 8 c J e f J D Vr r I 9 A z I v A z D I Z S zs J 18 I I S I IZS r D -A kIz zs c zs 3 Damian Smedley Katy Wolstencroft Carole Goble Engbert O de Brock Andrew R Jones Helen E Parkinson members of the Coordination of Mouse Informatics Resources CASIMIR 6 Genotype-To-Phenotype GEN2PHEN Consortiums1 Ritsert C Jansen1 2 Abstract We present an extensible software model for the genotype and phenotype community XGAP. Readers can download a standard XGAP http or auto-generate a custom version using MOLGENIS with programming interfaces to R-software and web-services or user interfaces for biologists. XGAP has simple load formats for any type of genotype epigenotype transcript protein metabolite or other phenotype data. Current functionality includes tools ranging from eQTL analysis in mouse to genome-wide association studies in humans. Background Modern genetic and genomic technologies provide researchers with unprecedented amounts of raw and processed data. For example recent genetical genomics 1-3 studies have mapped gene expression eQTL protein abundance p QTL and metabolite abundance mQTL to genetic variation using genome-wide linkage and genome-wide association experiments on various microarray mass spectrometry and proton nuclear magnetic resonance NMR platforms and in a wide range of organisms including human 4-8 yeast 9 10 mouse 11 rat 12 Caenorhabditis elegans 13 and .
