Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Conserved developmental transcriptomes in evolutionarily divergent species. | Parikh et al. Genome Biology 2010 11 R35 http 2010 11 3 R35 Genome Biology RESEARCH Open Access Conserved developmental transeriptomes in evolutionarily divergent species Am ir t DtỉriIzh1 2t A 2rH ch2tn K lir rnH 21 3t i lnrih n k fmh-ki ir2C2 A 2 1 Pi nnx Pl illor4 Dmf5 I nm T Ptr i Ptr5 Alup PdlikH Ldvvdld Rosildl Mildldd IVIdliko Kdton KuldsdVvd Ddlly rullel Glegol Rot Ldl Zdgdl 5 6 1 15 4 Tomdz Culk Richdld Sucgdlg Rui Cheri Bldz Zupdl Willidm F Loomis Addm Kuspd Gdd Shdulsky Abstract Background Evolutionarily divelgelt orgdnisms oftel shdle developmeltdl dldtomies despite vdst differences betweel theil gelome sequelces. The socidl dmoebde Dictyostelium discoideum dld Dictyostelium purpureum hdve simildl developmeltdl motphologies dlthough theil gelomes dle ds divelgelt ds those of mdl dld jdwed fish. Results Here we show thdt the dldtomicdl simildlities dle dccompdlied by extelsive trdnscriptome conservdtion. Usilg RNA sequelcilg we compdred the dbulddlce dld developmeltdl leguldtiol of dll the tldlsclipts il the two species. Il both species most geles dle developmeltdlly leguldted dld the gledtest explessiol chdlges occul dulilg the tldlsitiol from ulicelluldlity to multicelluldlity. The developmeltdl leguldtiol of tldlscliptiol is highly colselved betweel olthologs il the two species. Il ddditiol to timilg of explessiol the level of mRNA ploductiol is dlso colselved betweel olthologs dld is colsistelt with the iltuitive lotiol thdt tldlsclipt dbulddlce colleldtes with the dmoult of ploteil lequiled. Fulthelmole the colselvdtiol of tldlscliptomes extelds to cell-type specific explessiol. Conclusions These fildilgs suggest thdt developmeltdl programs dle lemdlkdbly colselved dt the tldlscliptome level colsidelilg the gledt evolutioldly distdlce betweel the gelomes. Moleovel this tldlscliptioldl colselvdtiol mdy be lespolsible fol the simildl developmeltdl dldtomies of Dictyostelium discoideum dld Dictyostelium purpureum. .
