Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Microbial signaling and systems biology. | Brown Genome Biology 2010 11 302 http 2010 11 5 302 Genome Biology MEETING REPORT L Microbial signaling and systems biology Alistair JP Brown 1 Abstract A report of the symposium on Signaling and Systems Biology held during the Society for General Microbiology Spring Meeting 29-30 March 2010 Edinburgh UK. A two-day symposium on signaling and systems biology held recently in Edinburgh was attended by more than 1 000 microbiologists and covered both bacteria and eukaryotic systems. Systems biology means different things to different people. To some the desire to generate integrated views of biological systems is reflected in a drive to define global-interaction networks based on synthetic genetic interactions transcriptomic datasets proteomics protein-protein interaction data metabo-lomics glycomics and or some other form of omics . To others systems biology is more about the mathematical modeling of local relatively small-scale systems or processes to be able to predict with reasonable accuracy the dynamic behaviors of these processes or to reveal novel emergent properties. Most systems-biology sessions held during microbiology meetings emphasize the omics view. So it was good to enjoy a systems-biology symposium where the focus was on the modeling of dynamic responses of stochastic single-cell behavior and of population heterogeneity. A broad range of topics combined with the fact that many of the issues addressed by speakers were of broad relevance to other experimental systems meant that attendees were able to compare and contrast diverse systems with their own system of choice. This report describes some of the highlights in discussions of the impact of randomness on cellular behavior modeling of cell behavior phagocytosis and the development of new tools. The impact of stochasticity upon molecular and cellular behaviors The issue of molecular decision-making was addressed in the context of the phage lambda life cycle by Ido .
