Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Genomics through the lens of next-generation sequencing. | Capra et al. Genome Biology 2010 11 306 http 2010 11 6 306 w Genome Biology MEETING REPORT L Genomics through the lens of next-generation sequencing John A Capra1 Lucia Carbone2 Samantha J Riesenfeld1 and Jeffrey D Wall3 Abstract A report on the 23rd annual meeting on The Biology of Genomes 11-15 May 2010 Cold Spring Harbor USA. Recent advances in high-throughput sequencing technologies have greatly increased the scale and scope of genomics research and this was evident throughout the recent Biology of Genomes meeting at the Cold Spring Harbor Laboratory. Here we describe some highlights of the meeting. Functional and cancer genomics In one of several talks that investigated the causes dynamics and phenotypic effects of regulatory change Mike Snyder Stanford University Stanford USA used chromatin immunoprecipitation followed by DNA sequencing ChIP-seq to examine the variability in transcription factor binding among individuals in yeast Saccharomyces cerevisiae and human. In both species significant variation was observed and the amount of binding was strongly correlated with gene expression. Much of the observed binding variation could be associated with specific single nucleotide polymorphisms SNPs and structural changes to the genome. On the basis of the patterns of variation Snyder suggested that gene regulation may work like a government with global regulators and local regulators all having strong effects but with some focused on a more limited set of loci. Snyder s talk introduced two themes that appeared throughout the meeting the widespread adoption of high-throughput sequencing as an analysis strategy and a focus on identifying and understanding regulatory elements. Axel Visel Lawrence Berkeley National Laboratory Berkeley USA continued these themes in a Correspondence wallj@ institute for Human Genetics University of California San Francisco 513 Parnassus Ave San Francisco CA 94143 USA Full list of author .
