Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Genetic diversity in India and the inference of Eurasian population expansion. | Xing et al. Genome Biology 2010 11 R113 http 2010 11 11 R113 Genome Biology RESEARCH Open Access Genetic diversity in India and the inference of Eurasian population expansion 11 u . r I .I I s V 1V 1 A 0 A -s-f-lzit- 1 s I_Il I2 A I_Il I if1 A ZX I lz c r 2 A l A A I I 7r r2 A A I ỉ h -ì t I I D -ì m f h -ì I3 Jincnuan Xing W Scott vvatKins Ya Hu Chad D hutt ahiko Sabo Donna M Muzny Michael J Bamshad Richard A Gibbs2 Lynn B Jorde1 Full Yu2 Abstract Background Genetic studies of populations from the Indian subcontinent are of great interest because of India s large population size complex demographic history and unique social structure. Despite recent large-scale efforts in discovering human genetic variation India s vast reservoir of genetic diversity remains largely unexplored. Results To analyze an unbiased sample of genetic diversity in India and to investigate human migration history in Eurasia we resequenced one 100-Kb ENCODE region in 92 samples collected from three castes and one tribal group from the state of Andhra Pradesh in south India. Analyses of the four Indian populations along with eight HapMap populations 692 samples showed that 30 of all SNPs in the south Indian populations are not seen in HapMap populations. Several Indian populations such as the Yadava Mala Madiga and Irula have nucleotide diversity levels as high as those of HapMap African populations. Using unbiased allele-frequency spectra we investigated the expansion of human populations into Eurasia. The divergence time estimates among the major population groups suggest that Eurasian populations in this study diverged from Africans during the same time frame approximately 90 to 110 thousand years ago . The divergence among different Eurasian populations occurred more than 40 000 years after their divergence with Africans. Conclusions Our results show that Indian populations harbor large amounts of genetic variation that have not been surveyed adequately by public SNP .
