Điều này làm cho họ một thay thế tốt hơn nơi được chỉ định sử dụng mãn tính. NSAIDs uống có thể dễ dàng có sẵn và có hiệu quả để giảm đau, sốt và viêm nhiễm phát sinh từ nhiều nguyên nhân. Acetaminophen, mặc dù phân loại NSAIDs và được sử dụng trong việc giảm đau và sốt | Chapter 8 Nonsteroidal Anti-Inflammatory Drugs NSAIDs KEY NSAIDs are generally less potent anti-inflammatory agents than corticosteroids and have fewer adverse effects. This makes them a better alternative where chronic use is indicated. Oral NSAIDs are readily available and are effective for reducing pain fever and inflammation arising from a variety of causes. Acetaminophen though classified with the NSAIDs and used in reducing pain and fever has no anti-inflammatory effect. Topical NSAIDs work very well in reducing the pain associated with corneal injuries such as an abrasion or keratorefractive surgery. 64 Chapter 8 OphT Introduction Turn on the television and you will recognize athletes and celebrities proclaiming the benefits of these wonder drugs. Known as nonsteroidal anti-inflammatory drugs NSAIDs the brand names are known instantly Bayer Bufferin Tylenol Advil and the list goes on. Derivatives of aspirin the NSAIDs are probably the most commonly administered drugs. In tablet form they can be purchased OTC or by prescription for use in many conditions. Now topical NSAIDs are quickly gaining acceptance and popularity for their effectiveness in ophthalmic practice. Systemically NSAIDs decrease fever pain and inflammation. In the last chapter we discussed the process of inflammation. You may want to glance at Figure 7-1 to review. Both corticosteroids and NSAIDs reduce inflammation. Whereas corticosteroids act in a general manner to decrease production of several biochemicals NSAIDs specifically reduce the production of the prostaglandins. This is accomplished by inhibiting a specific substance called cyclooxygenase which is needed to make prostaglandins. The action of the NSAIDs is thus much more specific other routes are not affected and are available to respond as needed. Fever is one result of inflammation. The increasing temperature speeds up the body s metabolism enabling the body to fight disease and repair injury. NSAIDs act to lower elevated body .
