Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Injection drug use and patterns of highly active antiretroviral therapy use: an analysis of ALIVE, WIHS, and MACS cohorts. | BioMed Central AIDS Research and Therapy Research Open Access Injection drug use and patterns of highly active antiretroviral therapy use an analysis of ALIVE WIHS and MACS cohorts John D Morris Elizabeth T Golub Shruti H Mehta Lisa P Jacobson and Stephen J Gange Address Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA Email John D Morris - morris_j_99@ Elizabeth T Golub - egolub@ Shruti H Mehta - shmehta@ Lisa P Jacobson - ljacobso@ Stephen J Gange - sgange@ Corresponding author Published 6 June 2007 Received 10 September 2006 AIDS Research and Therapy 2007 4 12 doi l742-6405-4-l2 Accepted 6 June 2007 This article is available from http content 4 l l2 2007 Morris et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Sustained use of antiretroviral therapy has been consistently shown to be one of the primary predictors of long-term effectiveness. Switching and discontinuation reflect patient and provider decisions that may limit future treatment options. In this study we utilize data reported at semi-annual study visits from three prospective cohort studies the AIDS Link to IntraVenous Exposure ALIVE the Women s Interagency HIV Study WIHS and the Multicenter AIDS Cohort Study MACS to investigate determinants of HAART modification with a particular focus on reported injection drug use IDU . Methods Longitudinal data collected between l996 and 2004 contributed from 2 266 participants 37 with a reported history of IDU who reported initiating their first HAART regimen during follow-up were utilized. Separate proportional-hazards models were used to identify factors measured prior to .
