Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of HIV-1-related protein expression on cardiac and skeletal muscles from transgenic rats. | AIDS Research and Therapy BioMed Central Research Effect of HIV-1-related protein expression on cardiac and skeletal muscles from transgenic rats Jeffrey S Otis 1 Yaroslav I Ashikhmin2 Lou Ann S Brown3 and David M Guidot1 Address Pulmonary Allergy and Critical Care Medicine Atlanta VA Medical Center and Emory University School of Medicine 1670 Clairmont Road Decatur GA 30033 USA . Sechenov Moscow Medical Academy Moscow Russia and 3Department of Pediatrics Emory University School of Medicine 2015 Uppergate Drive Atlanta GA 30322 USA Email Jeffrey S Otis - jsotis@ Yaroslav I Ashikhmin - Lou Ann S Brown - David M Guidot - dguidot@ Corresponding author Open Access Published 25 April 2008 Received 21 December 2007 AIDS Research and Therapy 2008 5 8 doi 1742-6405-5-8 Accepted 25 April 2008 This article is available from http content 5 1 8 2008 Otis et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human immunodeficiency virus type 1 HIV-1 infection and the consequent acquired immunodeficiency syndrome AIDS has protean manifestations including muscle wasting and cardiomyopathy which contribute to its high morbidity. The pathogenesis of these myopathies remains partially understood and may include nutritional deficiencies biochemical abnormalities inflammation and other mechanisms due to viral infection and replication. Growing evidence has suggested that HIV-1-related proteins expressed by the host in response to viral infection including Tat and gp120 may also be involved in the pathophysiology of AIDS particularly in cells or tissues that are not directly infected with HIV-1. To explore the potentially .
