Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: Potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity. | AIDS Research and Therapy BioMed Central Research Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate a novel terpenoid derivative Potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity Héla Sa idi11 Mohammad-Ali Jenabian11 Bernard Gombert2 Charlotte Charpentier1 Aurèle Mannarini2 and Laurent Bélec 1 Address 1Laboratoire de Virologie Hôpital Européen Georges Pompidou and Université Paris Descartes Paris V Paris France and 2MGB Pharma Nĩmes France Email Héla Saidi - Mohammad-Ali Jenabian - ms_jenabian@ Bernard Gombert - bernardgombert@ Charlotte Charpentier - Aurèle Mannarini - aurelemannarini@ Laurent Bélec - prbelecl@ Corresponding author tEqual contributors Open Access Published 3 June 2008 Received 24 January 2008 AIDS Research and Therapy 2008 5 10 doi 1742-6405-5-10 Accepted 3 June 2008 This article is available from http content 5 1 10 2008 Saidi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Terpenoid derivatives originating from many plants species are interesting compounds with numerous biological effects such as anti-HIV-l activity. The zinc tetra-ascorbo-camphorate complex or Cl4 a new monoterpenoid derivative was evaluated in vitro for its anti-HIV-l activity on both R5- and X4-HIV-I infection of primary target cells macrophages dendritic cells and T cells and on HIV-l transfer from dendritic cells to T cells. Results The toxicity study was carried out in vitro and also with the
